somatic cell hybrid การใช้

• The resulting somatic cell hybrids contain individual fragments of the relevant genome.
• Determination of haplotypes can be done through molecular methods ( Allele Specific PCR, Somatic cell hybrids ).
• This type of cell fusion is widely used for the production of somatic cell hybrids and for nuclear transfer in mammalian cloning.
• In particular, in a study using somatic cell hybrids of XR-1 cells and human fibroblasts, Giaccia " et al . " ( 1989 ) showed that the XR-1 mutation was a recessive mutation; Giaccia " et al ", tentatively assigned this human gene the name  XRCC4 ( an abbreviation of  X-ray-complementing Chinese hamster gene 4 ) and determined that ( a ) the newly named XRCC4 gene biochemically restored the hamster defect to normal levels of resistance to gamma-ray radiation and bleomycin and ( b ) the XRCC4 gene restored the proficiency to repair DNA DSBs.